Ontology highlight
ABSTRACT:
SUBMITTER: Kirstein J
PROVIDER: S-EPMC1440321 | biostudies-literature | 2006 Apr
REPOSITORIES: biostudies-literature
Kirstein Janine J Schlothauer Tilman T Dougan David A DA Lilie Hauke H Tischendorf Gilbert G Mogk Axel A Bukau Bernd B Turgay Kürşad K
The EMBO journal 20060309 7
The AAA+ protein ClpC is not only involved in the removal of misfolded and aggregated proteins but also controls, through regulated proteolysis, key steps of several developmental processes in the Gram-positive bacterium Bacillus subtilis. In contrast to other AAA+ proteins, ClpC is unable to mediate these processes without an adaptor protein like MecA. Here, we demonstrate that the general activation of ClpC is based upon the ability of MecA to participate in the assembly of an active and subst ...[more]