Ontology highlight
ABSTRACT:
SUBMITTER: Volgraf M
PROVIDER: S-EPMC1447676 | biostudies-literature | 2006 Jan
REPOSITORIES: biostudies-literature
Volgraf Matthew M Gorostiza Pau P Numano Rika R Kramer Richard H RH Isacoff Ehud Y EY Trauner Dirk D
Nature chemical biology 20051211 1
The precise regulation of protein activity is fundamental to life. The allosteric control of an active site by a remote regulatory binding site is a mechanism of regulation found across protein classes, from enzymes to motors to signaling proteins. We describe a general approach for manipulating allosteric control using synthetic optical switches. Our strategy is exemplified by a ligand-gated ion channel of central importance in neuroscience, the ionotropic glutamate receptor (iGluR). Using stru ...[more]