Ontology highlight
ABSTRACT:
SUBMITTER: Urban AE
PROVIDER: S-EPMC1450206 | biostudies-literature | 2006 Mar
REPOSITORIES: biostudies-literature
Urban Alexander Eckehart AE Korbel Jan O JO Selzer Rebecca R Richmond Todd T Hacker April A Popescu George V GV Cubells Joseph F JF Green Roland R Emanuel Beverly S BS Gerstein Mark B MB Weissman Sherman M SM Snyder Michael M
Proceedings of the National Academy of Sciences of the United States of America 20060314 12
Deletions and amplifications of the human genomic sequence (copy number polymorphisms) are the cause of numerous diseases and a potential cause of phenotypic variation in the normal population. Comparative genomic hybridization (CGH) has been developed as a useful tool for detecting alterations in DNA copy number that involve blocks of DNA several kilobases or larger in size. We have developed high-resolution CGH (HR-CGH) to detect accurately and with relatively little bias the presence and exte ...[more]