Ontology highlight
ABSTRACT:
SUBMITTER: Farah JA
PROVIDER: S-EPMC1456079 | biostudies-literature | 2005 Dec
REPOSITORIES: biostudies-literature
Farah Joseph A JA Cromie Gareth G Davis Luther L Steiner Walter W WW Smith Gerald R GR
Genetics 20050822 4
Spo11 or a homologous protein appears to be essential for meiotic DNA double-strand break (DSB) formation and recombination in all organisms tested. We report here the first example of an alternative, mutationally activated pathway for meiotic recombination in the absence of Rec12, the Spo11 homolog of Schizosaccharomyces pombe. Rad2, a FEN-1 flap endonuclease homolog, is involved in processing Okazaki fragments. In its absence, meiotic recombination and proper segregation of chromosomes were re ...[more]