Ontology highlight
ABSTRACT:
SUBMITTER: Valenta T
PROVIDER: S-EPMC1478201 | biostudies-literature | 2006 Jun
REPOSITORIES: biostudies-literature
Valenta Tomas T Lukas Jan J Doubravska Lenka L Fafilek Bohumil B Korinek Vladimir V
The EMBO journal 20060525 11
The hypermethylated in cancer 1 (HIC1) gene is epigenetically inactivated in cancer, and in addition, the haploinsufficiency of HIC1 is linked to the development of human Miller-Dieker syndrome. HIC1 encodes a zinc-finger transcription factor that acts as a transcriptional repressor. Additionally, the HIC1 protein oligomerizes via the N-terminal BTB/POZ domain and forms discrete nuclear structures known as HIC1 bodies. Here, we provide evidence that HIC1 antagonizes the TCF/beta-catenin-mediated ...[more]