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IL-15R alpha expression on CD8+ T cells is dispensable for T cell memory.

ABSTRACT: The generation and maintenance of immunological memory requires the activation, expansion, and persistent proliferation of antigen-specific T cells. Recent work suggests that IL-15 may be important for this process. Surprisingly, we now find that expression of the high-affinity receptor for IL-15, IL-15R alpha, on T cells is dispensable for the generation or maintenance of memory CD8(+) T cells. By contrast, IL-15R alpha expression on cells other than T cells is absolutely critical for this function. These findings may be related to IL-15R alpha's ability to present IL-15 in trans to low-affinity IL-15R beta gamma(c) receptors on memory CD8(+) T cells. These unexpected results provide insights into how IL-15R alpha supports memory CD8(+) T cells.

SUBMITTER: Burkett PR

PROVIDER: S-EPMC153623 | biostudies-literature | 2003 Apr

REPOSITORIES: biostudies-literature

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IL-15R alpha expression on CD8+ T cells is dispensable for T cell memory.

Burkett Patrick R PR Koka Rima R Chien Marcia M Chai Sophia S Chan Faye F Ma Averil A Boone David L DL

Proceedings of the National Academy of Sciences of the United States of America 20030401 8

The generation and maintenance of immunological memory requires the activation, expansion, and persistent proliferation of antigen-specific T cells. Recent work suggests that IL-15 may be important for this process. Surprisingly, we now find that expression of the high-affinity receptor for IL-15, IL-15R alpha, on T cells is dispensable for the generation or maintenance of memory CD8(+) T cells. By contrast, IL-15R alpha expression on cells other than T cells is absolutely critical for this func ...[more]

PMID: 12671073

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