Poxvirus CD8+ T-cell determinants and cross-reactivity in BALB/c mice.
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ABSTRACT:
SUBMITTER: Tscharke DC
PROVIDER: S-EPMC1488955 | biostudies-literature | 2006 Jul
REPOSITORIES: biostudies-literature
Publications
Poxvirus CD8+ T-cell determinants and cross-reactivity in BALB/c mice.
Tscharke David C DC Woo Wai-Ping WP Sakala Isaac G IG Sidney John J Sette Alessandro A Moss Denis J DJ Bennink Jack R JR Karupiah Gunasegaran G Yewdell Jonathan W JW
Journal of virology 20060701 13
Mouse models of orthopoxvirus disease provide great promise for probing basic questions regarding host responses to this group of pathogens, which includes the causative agents of monkeypox and smallpox. However, some essential tools for their study that are taken for granted with other mouse models are not available for these viruses. Here we map and characterize the initial CD8+ T-cell determinants for poxviruses in H-2d-haplotype mice. CD8+ T cells recognizing these three determinants make up ...[more]
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