CD8 controls T cell cross-reactivity.
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ABSTRACT:
SUBMITTER: Wooldridge L
PROVIDER: S-EPMC3018649 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Publications
CD8 controls T cell cross-reactivity.
Wooldridge Linda L Laugel Bruno B Ekeruche Julia J Clement Mathew M van den Berg Hugo A HA Price David A DA Sewell Andrew K AK
Journal of immunology (Baltimore, Md. : 1950) 20100915 8
Estimates of human αβ TCR diversity suggest that there are <10(8) different Ag receptors in the naive T cell pool, a number that is dwarfed by the potential number of different antigenic peptide-MHC (pMHC) molecules that could be encountered. Consequently, an extremely high degree of cross-reactivity is essential for effective T cell immunity. Ag recognition by T cells is unique in that it involves a coreceptor that binds at a site distinct from the TCR to facilitate productive engagement of the ...[more]
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