Ontology highlight
ABSTRACT:
SUBMITTER: Wang R
PROVIDER: S-EPMC3458792 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Wang Rui R Mellem Jerry E JE Jensen Michael M Brockie Penelope J PJ Walker Craig S CS Hoerndli Frédéric J FJ Hauth Linda L Madsen David M DM Maricq Andres V AV
Neuron 20120901 5
The neurotransmitter glutamate mediates excitatory synaptic transmission by gating ionotropic glutamate receptors (iGluRs). AMPA receptors (AMPARs), a subtype of iGluR, are strongly implicated in synaptic plasticity, learning, and memory. We previously discovered two classes of AMPAR auxiliary proteins in C. elegans that modify receptor kinetics and thus change synaptic transmission. Here, we have identified another auxiliary protein, SOL-2, a CUB-domain protein that associates with both the rel ...[more]