Ontology highlight
ABSTRACT:
SUBMITTER: Daudelin JF
PROVIDER: S-EPMC3591162 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Daudelin Jean-François JF Mathieu Mélissa M Boulet Salix S Labrecque Nathalie N
BioMed research international 20121230
Following activation, naïve CD8(+) T cells will differentiate into effectors that differ in their ability to survive: some will persist as memory cells while the majority will die by apoptosis. Signals given by antigen-presenting cells (APCs) at the time of priming modulate this differential outcome. We have recently shown that, in opposition to dendritic cell (DC), CD40-activated B-(CD40-B) cell vaccination fails to efficiently produce CD8(+) memory T cells. Understanding why CD40-B-cell vaccin ...[more]