Ontology highlight
ABSTRACT:
SUBMITTER: Qin G
PROVIDER: S-EPMC1544166 | biostudies-literature | 2006 Jul
REPOSITORIES: biostudies-literature
Qin Gangjian G Kishore Raj R Dolan Christine M CM Silver Marcy M Wecker Andrea A Luedemann Corinne N CN Thorne Tina T Hanley Allison A Curry Cynthia C Heyd Lindsay L Dinesh Deepika D Kearney Marianne M Martelli Fabio F Murayama Toshinori T Goukassian David A DA Zhu Yan Y Losordo Douglas W DW
Proceedings of the National Academy of Sciences of the United States of America 20060711 29
The transcription factor E2F1 is known to regulate cell proliferation and has been thought to modulate tumorigenesis via this mechanism alone. Here we show that mice deficient in E2F1 exhibit enhanced angiogenesis. The proangiogenic phenotype in E2F1 deficiency is the result of overproduction of vascular endothelial growth factor (VEGF) and is prevented by VEGF blockade. Under hypoxic conditions, E2F1 down-regulates the expression of VEGF promoter activity by associating with p53 and specificall ...[more]