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TRF2 acts as a transcriptional regulator in tumor angiogenesis.


ABSTRACT: We recently showed that telomeric repeat-binding factor 2 (TRF2) regulates gene expression to promote angiogenesis. We found that TRF2 is highly expressed in tumor vessels and transcriptionally activates platelet-derived growth factor receptor β to promote endothelial cell angiogenic properties independently of its function in telomere protection. This work identifies TRF2 as a promising dual target for cancer therapy.

SUBMITTER: Mai ME 

PROVIDER: S-EPMC4905305 | biostudies-other | 2015 Jul-Sep

REPOSITORIES: biostudies-other

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