Ontology highlight
ABSTRACT:
SUBMITTER: Ou YH
PROVIDER: S-EPMC1994125 | biostudies-literature | 2007 Sep
REPOSITORIES: biostudies-literature
Ou Yi-Hung YH Chung Pei-Han PH Hsu Fu-Fei FF Sun Te-Ping TP Chang Wen-Ying WY Shieh Sheau-Yann SY
The EMBO journal 20070809 17
Proper regulation of cell cycle progression is pivotal for maintaining genome stability. In a search for DNA damage-inducible, CHK1-modulated genes, we have identified BTG3 (B-cell translocation gene 3) as a direct p53 target. The p53 transcription factor binds to a consensus sequence located in intron 2 of the gene both in vitro and in vivo, and depletion of p53 by small interfering RNA (siRNA) abolishes DNA damage-induced expression of the gene. Furthermore, ablation of BTG3 by siRNA in cancer ...[more]