Ontology highlight
ABSTRACT:
SUBMITTER: Payandeh J
PROVIDER: S-EPMC1553185 | biostudies-literature | 2006 Aug
REPOSITORIES: biostudies-literature
The EMBO journal 20060810 16
We describe the CorA Mg(2+) transporter homologue from Thermotoga maritima in complex with 12 divalent cations at 3.7 A resolution. One metal is found near the universally conserved GMN motif, apparently stabilized within the transmembrane region. This portion of the selectivity filter might discriminate between the size and preferred coordination geometry of hydrated substrates. CorA may further achieve specificity by requiring the sequential dehydration of substrates along the length of its ap ...[more]