Ontology highlight
ABSTRACT:
SUBMITTER: Gallina G
PROVIDER: S-EPMC1578632 | biostudies-literature | 2006 Oct
REPOSITORIES: biostudies-literature
Gallina Giovanna G Dolcetti Luigi L Serafini Paolo P De Santo Carmela C Marigo Ilaria I Colombo Mario P MP Basso Giuseppe G Brombacher Frank F Borrello Ivan I Zanovello Paola P Bicciato Silvio S Bronte Vincenzo V
The Journal of clinical investigation 20061001 10
Active suppression of tumor-specific T lymphocytes can limit the efficacy of immune surveillance and immunotherapy. While tumor-recruited CD11b+ myeloid cells are known mediators of tumor-associated immune dysfunction, the true nature of these suppressive cells and the fine biochemical pathways governing their immunosuppressive activity remain elusive. Here we describe a population of circulating CD11b+IL-4 receptor alpha+ (CD11b+IL-4Ralpha+), inflammatory-type monocytes that is elicited by grow ...[more]