Ontology highlight
ABSTRACT:
SUBMITTER: Pattacini L
PROVIDER: S-EPMC6717561 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Mucosal immunology 20190716 5
The immune system of the cervicovaginal tract (CVT) must balance immunosurveillance and active immunity against pathogens with maintenance of tolerance to resident microbiota and to fetal and partner antigens for reproductive purposes. Thus, we predicted that CVT immunity is characterized by distinctive features compared to blood and other tissue compartments. Indeed, we found that CVT CD8+ T-cells had unique transcriptional profiles, particularly in their cytokine signature, compared to that re ...[more]