Ontology highlight
ABSTRACT:
SUBMITTER: Ishiguro K
PROVIDER: S-EPMC1592706 | biostudies-literature | 2006 Jul
REPOSITORIES: biostudies-literature
Ishiguro Kazuhiro K Green Todd T Rapley Joseph J Wachtel Heather H Giallourakis Cosmas C Landry Aimee A Cao Zhifang Z Lu Naifang N Takafumi Ando A Goto Hidemi H Daly Mark J MJ Xavier Ramnik J RJ
Molecular and cellular biology 20060701 14
CARMA1 is a central regulator of NF-kappaB activation in lymphocytes. CARMA1 and Bcl10 functionally interact and control NF-kappaB signaling downstream of the T-cell receptor (TCR). Computational analysis of expression neighborhoods of CARMA1-Bcl10MALT 1 for enrichment in kinases identified calmodulin-dependent protein kinase II (CaMKII) as an important component of this pathway. Here we report that Ca(2+)/CaMKII is redistributed to the immune synapse following T-cell activation and that CaMKII ...[more]