Ontology highlight
ABSTRACT:
SUBMITTER: Gao H
PROVIDER: S-EPMC1599986 | biostudies-literature | 2006 Sep
REPOSITORIES: biostudies-literature
Gao Hui H Ouyang Xuesong X Banach-Petrosky Whitney A WA Gerald William L WL Shen Michael M MM Abate-Shen Cory C
Proceedings of the National Academy of Sciences of the United States of America 20060914 39
Androgen independence is responsible for most prostate cancer lethality, yet currently there are no effective clinical treatments. We have been investigating the mechanisms underlying androgen-independent prostate cancer in Nkx3.1;Pten mutant mice, which display salient features of the disease, including a requirement for wild-type androgen receptor (AR) signaling. We now demonstrate that the Akt and Erk MAP kinase signaling pathways are activated in androgen-independent lesions of these mice. F ...[more]