Ontology highlight
ABSTRACT:
SUBMITTER: Drosten M
PROVIDER: S-EPMC4210339 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Drosten Matthias M Sum Eleanor Y M EY Lechuga Carmen G CG Simón-Carrasco Lucía L Jacob Harrys K C HK García-Medina Raquel R Huang Sidong S Beijersbergen Roderick L RL Bernards Rene R Barbacid Mariano M
Proceedings of the National Academy of Sciences of the United States of America 20141006 42
The Ras family of small GTPases constitutes a central node in the transmission of mitogenic stimuli to the cell cycle machinery. The ultimate receptor of these mitogenic signals is the retinoblastoma (Rb) family of pocket proteins, whose inactivation is a required step to license cell proliferation. However, little is known regarding the molecular events that connect Ras signaling with the cell cycle. Here, we provide genetic evidence to illustrate that the p53/p21 Cdk-interacting protein 1 (Cip ...[more]