Ontology highlight
ABSTRACT:
SUBMITTER: Heichinger C
PROVIDER: S-EPMC1630417 | biostudies-literature | 2006 Nov
REPOSITORIES: biostudies-literature
The EMBO journal 20061019 21
Eukaryotic DNA replication is initiated from multiple origins of replication, but little is known about the global regulation of origins throughout the genome or in different types of cell cycles. Here, we identify 401 strong origins and 503 putative weaker origins spaced in total every 14 kb throughout the genome of the fission yeast Schizosaccharomyces pombe. The same origins are used during premeiotic and mitotic S-phases. We found that few origins fire late in mitotic S-phase and that activa ...[more]