Ontology highlight
ABSTRACT:
SUBMITTER: Patel PK
PROVIDER: S-EPMC1345668 | biostudies-literature | 2006 Jan
REPOSITORIES: biostudies-literature
Patel Prasanta K PK Arcangioli Benoit B Baker Stephen P SP Bensimon Aaron A Rhind Nicholas N
Molecular biology of the cell 20051026 1
DNA replication initiates at discrete origins along eukaryotic chromosomes. However, in most organisms, origin firing is not efficient; a specific origin will fire in some but not all cell cycles. This observation raises the question of how individual origins are selected to fire and whether origin firing is globally coordinated to ensure an even distribution of replication initiation across the genome. We have addressed these questions by determining the location of firing origins on individual ...[more]