MsrR, a putative cell envelope-associated element involved in Staphylococcus aureus sarA attenuation.
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ABSTRACT:
SUBMITTER: Rossi J
PROVIDER: S-EPMC166063 | biostudies-literature | 2003 Aug
REPOSITORIES: biostudies-literature
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MsrR, a putative cell envelope-associated element involved in Staphylococcus aureus sarA attenuation.
Rossi Jutta J Bischoff Markus M Wada Akihito A Berger-Bächi Brigitte B
Antimicrobial agents and chemotherapy 20030801 8
A novel membrane-associated protein, MsrR, was identified in Staphylococcus aureus which affects resistance to methicillin and teicoplanin, as well as the synthesis of virulence factors. MsrR belongs to the LytR-CpsA-Psr family of cell envelope-related transcriptional attenuators and was shown to be inducible by cell wall-active agents, such as beta-lactams, glycopeptides, and lysostaphin. The expression of msrR peaked in the early exponential growth phase and decreased sharply thereafter. msrR ...[more]
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