Ontology highlight
ABSTRACT:
SUBMITTER: Davis JH
PROVIDER: S-EPMC1705752 | biostudies-literature | 2007 Jan
REPOSITORIES: biostudies-literature
Davis Jared H JH Foster Trenton R TR Tonelli Marco M Butcher Samuel E SE
RNA (New York, N.Y.) 20061121 1
Metal ions are critical for the proper folding of RNA, and the GAAA tetraloop-receptor is necessary for the optimal folding and function of many RNAs. We have used NMR to investigate the role of metal ions in the structure of the tetraloop-receptor in solution. The NMR data indicate native tertiary structure is formed under a wide range of ionic conditions. The lack of conformational adaptation in response to very different ionic conditions argues against a structural role for divalent ions. Nuc ...[more]