Ontology highlight
ABSTRACT:
SUBMITTER: Reggiori F
PROVIDER: S-EPMC1762033 | biostudies-literature | 2005 Jul
REPOSITORIES: biostudies-literature
Reggiori Fulvio F Shintani Takahiro T Nair Usha U Klionsky Daniel J DJ
Autophagy 20050711 2
Autophagy is a degradative process conserved among eukaryotic cells. It allows the elimination of cytoplasm including aberrant protein aggregates and damaged organelles. Accordingly, it is implicated in normal developmental processes and also serves a protective role in tumor suppression and elimination of invading pathogens, whereas defects in autophagy are associated with various human diseases including cancer and neurodegeneration. Atg proteins mediate the sequestration event that occurs at ...[more]