Ontology highlight
ABSTRACT:
SUBMITTER: Seymour PA
PROVIDER: S-EPMC1794281 | biostudies-literature | 2007 Feb
REPOSITORIES: biostudies-literature
Seymour Philip A PA Freude Kristine K KK Tran Man N MN Mayes Erin E EE Jensen Jan J Kist Ralf R Scherer Gerd G Sander Maike M
Proceedings of the National Academy of Sciences of the United States of America 20070131 6
The factors necessary to maintain organ-specific progenitor cells are poorly understood and yet of extreme clinical importance. Here, we identify the transcription factor SOX9 as the first specific marker and maintenance factor of multipotential progenitors during pancreas organogenesis. In the developing pancreas, SOX9 expression is restricted to a mitotically active, Notch-responsive subset of PDX1(+) pluripotent progenitors and is absent from committed endocrine precursors or differentiated c ...[more]