Ontology highlight
ABSTRACT:
SUBMITTER: Lazure F
PROVIDER: S-EPMC7726801 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Lazure Felicia F Blackburn Darren M DM Corchado Aldo H AH Sahinyan Korin K Karam Nabila N Sharanek Ahmad A Nguyen Duy D Lepper Christoph C Najafabadi Hamed S HS Perkins Theodore J TJ Jahani-Asl Arezu A Soleimani Vahab D VD
EMBO reports 20201013 12
The function and maintenance of muscle stem cells (MuSCs) are tightly regulated by signals originating from their niche environment. Skeletal myofibers are a principle component of the MuSC niche and are in direct contact with the muscle stem cells. Here, we show that Myf6 establishes a ligand/receptor interaction between muscle stem cells and their associated muscle fibers. Our data show that Myf6 transcriptionally regulates a broad spectrum of myokines and muscle-secreted proteins in skeletal ...[more]