The chemokine and chemokine receptor superfamilies and their molecular evolution.
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ABSTRACT:
SUBMITTER: Zlotnik A
PROVIDER: S-EPMC1794421 | biostudies-literature | 2006
REPOSITORIES: biostudies-literature
Publications
The chemokine and chemokine receptor superfamilies and their molecular evolution.
Zlotnik Albert A Yoshie Osamu O Nomiyama Hisayuki H
Genome biology 20060101 12
The human chemokine superfamily currently includes at least 46 ligands, which bind to 18 functionally signaling G-protein-coupled receptors and two decoy or scavenger receptors. The chemokine ligands probably comprise one of the first completely known molecular superfamilies. The genomic organization of the chemokine ligand genes and a comparison of their sequences between species shows that tandem gene duplication has taken place independently in the mouse and human lineages of some chemokine f ...[more]
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