Ontology highlight
ABSTRACT:
SUBMITTER: Ishida M
PROVIDER: S-EPMC1800732 | biostudies-literature | 2007 Feb
REPOSITORIES: biostudies-literature
Ishida Michiko M Miyamoto Mamiko M Naitoh Sayu S Tatsuda Daisuke D Hasegawa Tadashi T Nemoto Takeshi T Yokozeki Hiroo H Nishioka Kiyoshi K Matsukage Akio A Ohki Misao M Ohta Tsutomu T
Molecular and cellular biology 20061113 4
Chromosomal translocations are frequently associated with soft-tissue sarcomas. Fusion proteins generated by such translocations often play critical roles in tumorigenesis. Therefore, it is important to understand the function of the fusion protein to develop therapeutic interventions. The t(X;18)(p11.2;q11.2) translocation found in synovial sarcomas results in a fusion between the SYT gene on chromosome 18 and an SSX gene on the X chromosome. Although SYT-SSX fusion proteins appear to trigger s ...[more]