Ontology highlight
ABSTRACT:
SUBMITTER: Kawaguchi S
PROVIDER: S-EPMC7659233 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Kawaguchi Satoshi S Tsukahara Tomohide T Ida Kazunori K Kimura Shigeharu S Murase Masaki M Kano Masanobu M Emori Makoto M Nagoya Satoshi S Kaya Mitsunori M Torigoe Toshihiko T Ueda Emiri E Takahashi Akari A Ishii Takeshi T Tatezaki Shin-ichiro S Toguchida Junya J Tsuchiya Hiroyuki H Osanai Toshihisa T Sugita Takashi T Sugiura Hideshi H Ieguchi Makoto M Ihara Koichiro K Hamada Ken-ichiro K Kakizaki Hiroshi H Morii Takeshi T Yasuda Taketoshi T Tanizawa Taisuke T Ogose Akira A Yabe Hiroo H Yamashita Toshihiko T Sato Noriyuki N Wada Takuro T
Cancer science 20120807 9
In the present study, we evaluated the safety and effectiveness of SYT-SSX-derived peptide vaccines in patients with advanced synovial sarcoma. A 9-mer peptide spanning the SYT-SSX fusion region (B peptide) and its HLA-A*2402 anchor substitute (K9I) were synthesized. In Protocols A1 and A2, vaccines with peptide alone were administered subcutaneously six times at 14-day intervals. The B peptide was used in Protocol A1, whereas the K9I peptide was used in Protocol A2. In Protocols B1 and B2, the ...[more]