Ontology highlight
ABSTRACT:
SUBMITTER: Eswarakumar VP
PROVIDER: S-EPMC1820687 | biostudies-literature | 2007 Mar
REPOSITORIES: biostudies-literature
Eswarakumar Veraragavan P VP Schlessinger Joseph J
Proceedings of the National Academy of Sciences of the United States of America 20070223 10
Fibroblast growth factor receptor 3 (FGFR3) plays an important role in the control of chondrocyte proliferation and differentiation, a process critical for normal development of the skeleton. To reveal the contributions of the epithelial Fgfr3b isoform and the mesenchymal Fgfr3c isoform to skeletal overgrowth seen in mice, in which both isoforms have been inactivated (Fgf3c(-/-) mice), we have generated mice in which each of the two Fgfr3 isoforms has been selectively inactivated. Whereas no app ...[more]