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Innate response to self-antigen significantly exacerbates burn wound depth.

ABSTRACT: A major component of burn injury is caused by additional local damage from acute inflammation. Using a scald burn model in mice, we find that this part of the injury is dependent on recognition of self-antigen by specific natural IgM, leading to activation of the complement system. We propose that the depth of a burn wound is a sum of the thermal energy applied and of the degree of host inflammatory response.

SUBMITTER: Suber F

PROVIDER: S-EPMC1820693 | biostudies-literature | 2007 Mar

REPOSITORIES: biostudies-literature

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Innate response to self-antigen significantly exacerbates burn wound depth.

Suber Freeman F Carroll Michael C MC Moore Francis D FD

Proceedings of the National Academy of Sciences of the United States of America 20070228 10

A major component of burn injury is caused by additional local damage from acute inflammation. Using a scald burn model in mice, we find that this part of the injury is dependent on recognition of self-antigen by specific natural IgM, leading to activation of the complement system. We propose that the depth of a burn wound is a sum of the thermal energy applied and of the degree of host inflammatory response. ...[more]

PMID: 17360462

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