No gene is an island: the flip-flop phenomenon.
Ontology highlight
ABSTRACT:
SUBMITTER: Lin PI
PROVIDER: S-EPMC1821115 | biostudies-literature | 2007 Mar
REPOSITORIES: biostudies-literature
Publications
No gene is an island: the flip-flop phenomenon.
Lin Ping-I PI Vance Jeffery M JM Pericak-Vance Margaret A MA Martin Eden R ER
American journal of human genetics 20070122 3
An increasing number of publications are replicating a previously reported disease-marker association but with the risk allele reversed from the previous report. Do such "flip-flop" associations confirm or refute the previous association findings? We hypothesized that these associations may indeed be confirmations but that multilocus effects and variation in interlocus correlations contribute to this flip-flop phenomenon. We used theoretical modeling to demonstrate that flip-flop associations ca ...[more]
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