Ontology highlight
ABSTRACT:
SUBMITTER: Lusso P
PROVIDER: S-EPMC1829265 | biostudies-literature | 2007 Mar
REPOSITORIES: biostudies-literature
Lusso Paolo P Crowley Richard W RW Malnati Mauro S MS Di Serio Clelia C Ponzoni Maurilio M Biancotto Angelique A Markham Phillip D PD Gallo Robert C RC
Proceedings of the National Academy of Sciences of the United States of America 20070314 12
Although HIV is the necessary and sufficient causative agent of AIDS, genetic and environmental factors markedly influence the pace of disease progression. Clinical and experimental evidence suggests that human herpesvirus 6A (HHV-6A), a cytopathic T-lymphotropic DNA virus, fosters the progression to AIDS in synergy with HIV-1. In this study, we investigated the effect of coinfection with HHV-6A on the progression of simian immunodeficiency virus (SIV) disease in pig-tailed macaques (Macaca neme ...[more]