Human herpesvirus 6A partially suppresses functional properties of DC without viral replication.
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ABSTRACT:
SUBMITTER: Gustafsson RK
PROVIDER: S-EPMC3590851 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
Human herpesvirus 6A partially suppresses functional properties of DC without viral replication.
Gustafsson Rasmus K L RK Engdahl Elin E EE Hammarfjord Oscar O Adikari Sanjaya B SB Lourda Magda M Klingström Jonas J Svensson Mattias M Fogdell-Hahn Anna A
PloS one 20130305 3
Human herpesvirus 6A (HHV-6A) is a common virus with a worldwide distribution that has been associated with multiple sclerosis. Whether HHV-6A can replicate in dendritic cells (DC) and how the infection might modulate the functional properties of the cell are currently not well known and need further investigations. Here, we show that a non-productive infection of HHV-6A in DC leads to the up-regulation of HLA-ABC, via autocrine IFN-α signaling, as well as the up-regulation of HLA-DR and CD86. H ...[more]
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