Ontology highlight
ABSTRACT:
SUBMITTER: Xu Y
PROVIDER: S-EPMC1831826 | biostudies-literature | 2007 Mar
REPOSITORIES: biostudies-literature
Xu Yucheng Y Zhou Yan Larry YL Erickson Robin L RL Macdougald Ormond A OA Snead Malcolm L ML
Biochemical and biophysical research communications 20070102 1
The amelogenin gene is tightly regulated at the temporal and spatial level in accord with the developmental requirement for tooth formation. Previous studies have shown that CCAAT/enhancer-binding protein alpha (C/EBPalpha) is a transactivator of the mouse X-chromosomal amelogenin gene. C/EBPalpha contains four highly conserved regions (CR) named CR1, CR2, CR3, and CR4. Transient transfection assays showed that CR2 in isolation had an exceptional capacity to enhance transcription from the 2.3 kb ...[more]