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Toward the Total Synthesis of Scleritodermin A: Preparation of the C(1)-N(15) Fragment.

ABSTRACT: The synthesis of the C(1)-N(15) fragment of the marine natural product Scleritodermin A has been accomplished through a short and stereocontrolled sequence. Highlights of this route include the synthesis of the novel ACT fragment and the formation of the alpha-keto amide linkage by the use of a highly activated alpha, beta-ketonitrile.

SUBMITTER: Sellanes D

PROVIDER: S-EPMC1832122 | biostudies-literature | 2007 Mar

REPOSITORIES: biostudies-literature

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Toward the Total Synthesis of Scleritodermin A: Preparation of the C(1)-N(15) Fragment.

Sellanes Diver D Manta Eduardo E Serra Gloria G

Tetrahedron letters 20070301 10

The synthesis of the C(1)-N(15) fragment of the marine natural product Scleritodermin A has been accomplished through a short and stereocontrolled sequence. Highlights of this route include the synthesis of the novel ACT fragment and the formation of the alpha-keto amide linkage by the use of a highly activated alpha, beta-ketonitrile. ...[more]

PMID: 18320006

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