Proteinase-Activated Receptor 1 (PAR1) regulates leukemic stem cell functions.
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ABSTRACT:
SUBMITTER: Baumer N
PROVIDER: S-EPMC3989293 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
Proteinase-Activated Receptor 1 (PAR1) regulates leukemic stem cell functions.
Bäumer Nicole N Krause Annika A Köhler Gabriele G Lettermann Stephanie S Evers Georg G Hascher Antje A Bäumer Sebastian S Berdel Wolfgang E WE Müller-Tidow Carsten C Tickenbrock Lara L
PloS one 20140416 4
External signals that are mediated by specific receptors determine stem cell fate. The thrombin receptor PAR1 plays an important role in haemostasis, thrombosis and vascular biology, but also in tumor biology and angiogenesis. Its expression and function in hematopoietic stem cells is largely unknown. Here, we analyzed expression and function of PAR1 in primary hematopoietic cells and their leukemic counterparts. AML patients' blast cells expressed much lower levels of PAR1 mRNA and protein than ...[more]
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