Ontology highlight
ABSTRACT:
SUBMITTER: Zhang F
PROVIDER: S-EPMC1838613 | biostudies-literature | 2007 Mar
REPOSITORIES: biostudies-literature
Zhang Fan F Pomerantz Jason H JH Sen George G Palermo Adam T AT Blau Helen M HM
Proceedings of the National Academy of Sciences of the United States of America 20070307 11
DNA methylation is among the most stable epigenetic marks, ensuring tissue-specific gene expression in a heritable manner throughout development. Here we report that differentiated mesodermal somatic cells can confer tissue-specific changes in DNA methylation on epidermal progenitor cells after fusion in stable multinucleate heterokaryons. Myogenic factors alter regulatory regions of genes in keratinocyte cell nuclei, demethylating and activating a muscle-specific gene and methylating and silenc ...[more]