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Novel synthon for incorporating 1,3-dimethyl imidazolium group into molecular architecture.

ABSTRACT: The synthesized 1,3-dimethylated imidazolium carbaldehydes serves as synthons for incorporating a permanently cationic imidazolium group into molecular framework. The utility of new synthon was demonstrated in a variety of reactions: Knoevenagel, Wittig, Schiff base formation, based mediated electrophilic substitution and oxidation, including synthesis of the natural product norzooanemonin.

SUBMITTER: Berezin M

PROVIDER: S-EPMC1849869 | biostudies-literature | 2007 Feb

REPOSITORIES: biostudies-literature

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Novel synthon for incorporating 1,3-dimethyl imidazolium group into molecular architecture.

Berezin Mikhail M Achilefu Samuel S

Tetrahedron letters 20070201 7

The synthesized 1,3-dimethylated imidazolium carbaldehydes serves as synthons for incorporating a permanently cationic imidazolium group into molecular framework. The utility of new synthon was demonstrated in a variety of reactions: Knoevenagel, Wittig, Schiff base formation, based mediated electrophilic substitution and oxidation, including synthesis of the natural product norzooanemonin. ...[more]

PMID: 17417670

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