Ontology highlight
ABSTRACT:
SUBMITTER: Yu CY
PROVIDER: S-EPMC1855014 | biostudies-literature | 2007 May
REPOSITORIES: biostudies-literature
Yu Chun-Ying CY Chen Jen-Yau JY Lin Yu-Yu YY Shen Kuo-Fang KF Lin Wei-Ling WL Chien Chung-Liang CL ter Beest Martin B A MB Jou Tzuu-Shuh TS
Molecular biology of the cell 20070301 5
Podocalyxin/Gp135 was recently demonstrated to participate in the formation of a preapical complex to set up initial polarity in MDCK cells, a function presumably depending on the apical targeting of Gp135. We show that correct apical sorting of Gp135 depends on a bipartite signal composed of an extracellular O-glycosylation-rich region and the intracellular PDZ domain-binding motif. The function of this PDZ-binding motif could be substituted with a fusion construct of Gp135 with Ezrin-binding p ...[more]