Issues in the analysis of oligonucleotide tiling microarrays for transcript mapping.
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ABSTRACT:
SUBMITTER: Royce TE
PROVIDER: S-EPMC1855044 | biostudies-literature | 2005 Aug
REPOSITORIES: biostudies-literature
Publications
Issues in the analysis of oligonucleotide tiling microarrays for transcript mapping.
Royce Thomas E TE Rozowsky Joel S JS Bertone Paul P Samanta Manoj M Stolc Viktor V Weissman Sherman S Snyder Michael M Gerstein Mark M
Trends in genetics : TIG 20050801 8
Traditional microarrays use probes complementary to known genes to quantitate the differential gene expression between two or more conditions. Genomic tiling microarray experiments differ in that probes that span a genomic region at regular intervals are used to detect the presence or absence of transcription. This difference means the same sets of biases and the methods for addressing them are unlikely to be relevant to both types of experiment. We introduce the informatics challenges arising i ...[more]
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