Ontology highlight
ABSTRACT:
SUBMITTER: Sheth U
PROVIDER: S-EPMC1858659 | biostudies-literature | 2006 Jun
REPOSITORIES: biostudies-literature
Cell 20060601 6
In eukaryotes, a specialized pathway of mRNA degradation termed nonsense-mediated decay (NMD) functions in mRNA quality control by recognizing and degrading mRNAs with aberrant termination codons. We demonstrate that NMD in yeast targets premature termination codon (PTC)-containing mRNA to P-bodies. Upf1p is sufficient for targeting mRNAs to P-bodies, whereas Upf2p and Upf3p act, at least in part, downstream of P-body targeting to trigger decapping. The ATPase activity of Upf1p is required for N ...[more]