Ontology highlight
ABSTRACT:
SUBMITTER: Schneider MD
PROVIDER: S-EPMC2064231 | biostudies-literature | 2006 Jul
REPOSITORIES: biostudies-literature
Schneider Mary D MD Najand Nima N Chaker Sana S Pare Justin M JM Haskins Julie J Hughes Sarah C SC Hobman Tom C TC Locke John J Simmonds Andrew J AJ
The Journal of cell biology 20060701 3
In mammalian cells, the GW182 protein localizes to cytoplasmic bodies implicated in the regulation of messenger RNA (mRNA) stability, translation, and the RNA interference pathway. Many of these functions have also been assigned to analogous yeast cytoplasmic mRNA processing bodies. We have characterized the single Drosophila melanogaster homologue of the human GW182 protein family, which we have named Gawky (GW). Drosophila GW localizes to punctate, cytoplasmic foci in an RNA-dependent manner. ...[more]