Ontology highlight
ABSTRACT:
SUBMITTER: Sheth U
PROVIDER: S-EPMC1876714 | biostudies-literature | 2003 May
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20030501 5620
A major pathway of eukaryotic messenger RNA (mRNA) turnover begins with deadenylation, followed by decapping and 5' to 3' exonucleolytic decay. We provide evidence that mRNA decapping and 5' to 3' degradation occur in discrete cytoplasmic foci in yeast, which we call processing bodies (P bodies). First, proteins that activate or catalyze decapping are concentrated in P bodies. Second, inhibiting mRNA turnover before decapping leads to loss of P bodies; however, inhibiting turnover at, or after, ...[more]