Ontology highlight
ABSTRACT:
SUBMITTER: Sukhdeo K
PROVIDER: S-EPMC1863489 | biostudies-literature | 2007 May
REPOSITORIES: biostudies-literature
Sukhdeo Kumar K Mani Mala M Zhang Yunyu Y Dutta Jui J Yasui Hiroshi H Rooney Melissa D MD Carrasco Daniel E DE Zheng Mei M He Haiying H Tai Yu-Tzu YT Mitsiades Constantine C Anderson Kenneth C KC Carrasco Daniel R DR
Proceedings of the National Academy of Sciences of the United States of America 20070423 18
Multiple myeloma (MM) is an invariably fatal form of cancer characterized by clonal proliferation of malignant plasma cells in the bone marrow. The canonical Wnt signaling pathway is activated in MM cells through constitutively active beta-catenin, a messenger molecule relevant to growth, survival, and migration of MM cells. The identification of a number of small molecular compounds, such as PKF115-584, which disrupt the interaction of the transcriptionally active beta-catenin/TCF protein compl ...[more]