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Modulation at age of onset in tunisian huntington disease patients: implication of new modifier genes.

ABSTRACT: Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder. The causative mutation is an expansion of more than 36 CAG repeats in the first exon of IT15 gene. Many studies have shown that the IT15 interacts with several modifier genes to regulate the age at onset (AO) of HD. Our study aims to investigate the implication of CAG expansion and 9 modifiers in the age at onset variance of 15 HD Tunisian patients and to establish the correlation between these modifiers genes and the AO of this disease. Despite the small number of studied patients, this report consists of the first North African study in Huntington disease patients. Our results approve a specific effect of modifiers genes in each population.

SUBMITTER: Hmida-Ben Brahim D

PROVIDER: S-EPMC4164136 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Modulation at age of onset in tunisian huntington disease patients: implication of new modifier genes.

Hmida-Ben Brahim Dorra D Chourabi Marwa M Ben Amor Sana S Harrabi Imed I Trabelsi Saoussen S Haddaji-Mastouri Marwa M Gribaa Moez M Sassi Sihem S Gahbiche Fatma Ezzahra FE Lamouchi Turkia T Mougou-Zereli Soumaya S Ben Ammou Sofiane S Saad Ali A

Genetics research international 20140901

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder. The causative mutation is an expansion of more than 36 CAG repeats in the first exon of IT15 gene. Many studies have shown that the IT15 interacts with several modifier genes to regulate the age at onset (AO) of HD. Our study aims to investigate the implication of CAG expansion and 9 modifiers in the age at onset variance of 15 HD Tunisian patients and to establish the correlation between these modifiers genes and the ...[more]

PMID: 25254119

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