The landscape of genomic imprinting across diverse adult human tissues.
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ABSTRACT:
SUBMITTER: Baran Y
PROVIDER: S-EPMC4484390 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Publications
The landscape of genomic imprinting across diverse adult human tissues.
Baran Yael Y Subramaniam Meena M Biton Anne A Tukiainen Taru T Tsang Emily K EK Rivas Manuel A MA Pirinen Matti M Gutierrez-Arcelus Maria M Smith Kevin S KS Kukurba Kim R KR Zhang Rui R Eng Celeste C Torgerson Dara G DG Urbanek Cydney C Li Jin Billy JB Rodriguez-Santana Jose R JR Burchard Esteban G EG Seibold Max A MA MacArthur Daniel G DG Montgomery Stephen B SB Zaitlen Noah A NA Lappalainen Tuuli T
Genome research 20150507 7
Genomic imprinting is an important regulatory mechanism that silences one of the parental copies of a gene. To systematically characterize this phenomenon, we analyze tissue specificity of imprinting from allelic expression data in 1582 primary tissue samples from 178 individuals from the Genotype-Tissue Expression (GTEx) project. We characterize imprinting in 42 genes, including both novel and previously identified genes. Tissue specificity of imprinting is widespread, and gender-specific effec ...[more]
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