A new family-based association test via a least-squares method.
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ABSTRACT:
SUBMITTER: Yang S
PROVIDER: S-EPMC1866828 | biostudies-literature | 2005
REPOSITORIES: biostudies-literature
Publications
A new family-based association test via a least-squares method.
Yang Song S Joo Jungnam J Feng Ziding Z Lin Jing-Ping JP
BMC genetics 20051230
To test the association between a dichotomous phenotype and genetic marker based on family data, we propose a least-squares method using the vector of phenotypes and their cross products within each family. This new approach allows covariate adjustment and is numerically much simpler to implement compared to likelihood- based methods. The new approach is asymptotically equivalent to the generalized estimating equation approach with a diagonal working covariance matrix, thus avoiding some difficu ...[more]
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