Ontology highlight
ABSTRACT:
SUBMITTER: Li L
PROVIDER: S-EPMC1891667 | biostudies-literature | 2006 Apr
REPOSITORIES: biostudies-literature
Li Lei L Zhao Bing B Cui Zhanhua Z Gan Jacob J Sakharkar Meena Kishore MK Kangueane Pandjassarame P
Bioinformation 20060404 4
It is known that binding free energy of protein-protein interaction is mainly contributed by hot spot (high energy) interface residues. Here, we investigate the characteristics of hot spots by examining inter-atomic sidechain-sidechain interactions using a dataset of 296 alanine-mutated interface residues. Results show that hot spots participate in strong and energetically favorable sidechain-sidechain interactions. Subsequently, we describe a novel, yet simple 'hot spot' prediction model with a ...[more]