Ontology highlight
ABSTRACT:
SUBMITTER: Lise S
PROVIDER: S-EPMC3046169 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Lise Stefano S Buchan Daniel D Pontil Massimiliano M Jones David T DT
PloS one 20110228 2
Protein-protein interactions are critically dependent on just a few 'hot spot' residues at the interface. Hot spots make a dominant contribution to the free energy of binding and they can disrupt the interaction if mutated to alanine. Here, we present HSPred, a support vector machine(SVM)-based method to predict hot spot residues, given the structure of a complex. HSPred represents an improvement over a previously described approach (Lise et al, BMC Bioinformatics 2009, 10:365). It achieves high ...[more]